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ABSTRACT. Background: The dengue and chikungunya epidemics have major challenging problems and have become essentially a public health importance. The Chikungunya virus was isolated from mosquitoes and found to be identical to the AV circulating human strain. This is the first field study. Mosquitoes transmit numerous arboviruses including dengue and chikungunya virus (CHIKV). Chikungunya is a re-emerging arthropod-borne.

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Majalah Kedokteran Nusantara (Journal of Medical School)

The distribution of joint manifestations in the chronic form is similar to the acute, including symmetrical involvement of joints of the distal extremities, knee, shoulders, and rarely the back [ 2029323537 ]. Alternatively, induction of autoimmune disease following CHIKV infection has been put forth as a possible mechanism of chronic joint disease [ 23 ].

Those that have been reported describe vascular proliferation, perivascular macrophages, and synovial hyperplasia [ 37 ]. Dengue, chikungunya and Zika co-infection in a patient from Colombia. Additionally, pre-existing joint disease present at the time of initial infection and development of joint disease such as OA or RA unrelated to CHIKV infection cannot be ruled out.

A mean follow-up of two years. If received prior to infection, viremia and virus levels in ankles were decreased to below jurnl level of detection, however, when administered after infection, though viremia decreased, there were no effects on the levels of viral RNA in the inoculated foot [ 4 ]. We collected total of chikungunya and dengue cases in ten months November — August and secondary data on environmental variable includes population density, vegetation density, building density, land use, larvae index and climate.


While our knowledge in this area has greatly increased in recent years, the role of CHIKV in development of more chronic stages of disease has yet to be elucidated. Emerging viral infections in rheumatic diseases. In some cases, MRI demonstrated clear improvement in severity of joint swelling, and pain and tendon involvement continuing for 15 months after initiation [ 41 ].

Jurnal Biotek Medisiana Indonesia.

Some significant bony changes, such as obvious erosions, can be seen by months post infection p. Neutralizing IgM antibodies can also be found in the synovial fluid of patients 3 months after the initial infection [ 27 ]. In fact, a retrospective study examining patient outcome after the Reunion Outbreak demonstrated that patients with chronic post-CHIKV joint disease could be variably diagnosed with RA, spondyloarthropathies, undifferentiated polyarthritis or other musculoskeletal disorders [ 34 ].

Additionally, recommendations are presented regarding juranl for clinical research to help further elucidate the pathogenesis of joint disease associated jkrnal CHIKV infection. While many have shown promise in animal models as demonstrated by production of neutralizing antibodies and protection against viral challenge, few have moved into clinical trials.

Chikungunyashowedmore onthe malesex, and the productive age group It should also be noted that aspirin is not recommended due to bleeding risk [ 12 ]. chikungknya

An additional confounding factor is that presence or absence of pre-existing joint disease is often ascertained via self-reporting questionnaires, while thorough orthopedic evaluations at the time of or prior to initial infection are rarely performed [ 2933 – 36 ].

Therapeutics and vaccines against chikungunya virus. Other cases have demonstrated almost complete resolution of symptoms in months using methotrexate, sulfasalazine and hydroxychloroquine [ 37 ].

Post a Comment Login required. However, it should be noted that other arboviruses such as dengue, Zika, and other alphaviruses can have similar clinical presentations, including fever and arthralgia. Further study is needed to develop model in vector born early warning system using GIS and remote sensing.


Pre-existing joint disease has also often been associated with an increased susceptibility to development of chronic CHIKV-associated arthritis [ 24 ]. Studies have demonstrated positivity for rheumatoid factor RF in Control measures were already taken, but it seemed not effective, cases were spread and increased progressively by weeks and non-vector born disease which has similar sign and symptoms was thought to be the cause.

Interleukin 6, RANKL, and osteoprotegerin expression by chikungunya virus-infected human osteoblasts. How to cite item. Persistent arthralgia associated with chikungunya virus: Explosive re-emergence of chikungunya fever has been started since and affected millions people in worldwide i. Chikungunya fever in Canada: Currently, specific treatment modalities for acute and chronic CHIKV-induced disease do not exist, and the majority of treatment plans consist of supportive and symptomatic care.

Manifestasi Klinis Infeksi Virus Chikungunya Pada Kejadian Luar Biasa Di Indonesia – Neliti

Replication of virus occurs within the cytoplasm, associated with cytopathic vacuoles formed from rearrangement of host membranes [ 57 ]. The mechanisms involved in the development of the chronic or chikungjnya form of CHIKV-associated joint disease are poorly understood.

Journal List Open Rheumatol J v. The most joint pain symptom reported is wristand knee joints