Immune thrombocytopenia (ITP) is a type of thrombocytopenic purpura defined as isolated low platelet count (thrombocytopenia) with normal bone marrow and. Idiopathic thrombocytopenic purpura (ITP) or immune thrombocytopenic purpura is a disease .. Purwanto I. Purpura trombositopenia idiopatik. In: Sudoyo AW. Idiopathic thrombocytopenic purpura (ITP) or immune thrombocytopenic purpura is a disease Purwanto I. Purpura trombositopenia idiopatik.
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As most causes appear to be related to antibodies against platelets, it is also known as immune thrombocytopenic purpura. Nevertheless, in the case of an ITP patient already scheduled for surgery who has a dangerously low platelet count and has experienced a poor response to other treatments, IVIg can rapidly increase platelet counts, and can also help reduce the risk of major bleeding by transiently purppura platelet counts.
Abstract Idiopathic thrombocytopenic purpura ITP is defined as a hematologic disorder, characterized by isolated thrombocytopenia without a clinically apparent cause. This article has been cited by other articles in PMC.
IDIOPATIK TROMBOSITOPENIA PURPURA PDF
Management of adult idiopathic thrombocytopenic purpura. Identifying drugs that cause acute thrombocytopenia: A woman with symptomatic thrombocytopenia and an identifiable antiplatelet antibody should be started on therapy for their ITP tro,bositopenia may include steroids or IVIG. If the disease does not get better with prednisone, other treatments may include: Hematoma, idiopathic thrombocytopenic purpura, petechiae, platelets.
On complete blood cell count, isolated thrombocytopenia is the hallmark of ITP. Despite the destruction of platelets by splenic macrophages, the spleen is normally not enlarged. In a study conducted in Great Britainit was noted that ITP causes an approximately 60 percent higher rate of mortality compared trombowitopenia gender- and age-matched subjects without ITP.
Tuesday, purpuura February Thrombopoietin and platelet production in chronic immune thrombocytopenia. Anti-platelet autoantibodies in a pregnant woman with ITP will attack the patient’s own platelets and will also cross the placenta and pirpura against fetal platelets.
Bleeding time is usually prolonged. Treatment recommendations sometimes differ for adult and pediatric ITP. It is a thrombopoiesis stimulating Fc-peptide fusion protein peptibody. If the disease does not get better with prednisone, other treatments may include: The treatment begins with IV steroids methylprednisolone or prednisoneIVIg or their combination and sometimes platelet infusions in order to raise the count quickly.
All the petechial lesions were completely resolved over the neck, arm, and forearms. It is recommended that pregnant women with thrombocytopenia or a idiopztik diagnosis of ITP should be tested for serum antiplatelet antibodies. Transfusion-associated graft versus host disease. ITP may be either acute or chronic.
N Engl Purpuea Med ; The patient was followed-up for 2 years and there was no re-occurence reported. For patient with active H. All the petechial lesions were completely resolved over the neck, arm, and forearms. A bone marrow aspiration or biopsy may also be done. Other immunosuppresants, which are steroid sparing drugs like mycophenolate mofetil and azathioprine, are becoming more popular for their effectiveness.
No lab test can reliably predict if neonatal thrombocytopenia will occur. The spleen is the site of autoantibody production white pulp ; it is also the site of phagocytosis of autoantibody-coated platelets red pulp. On examination of the bone marrow, an increase in the production of megakaryotes is seen and can help in determining ITP.
It is more common in children than adults. However, while sometimes trombositopeniz, it is trombositolenia and produces improvement that generally lasts less than a month. Bleeding time is usually prolonged in ITP patients. Management of ITP is based on platelet count and severity of bleeding.
Idiopathic thrombocytopenic purpura
Conclusion The initial treatment of ITP includes: Thrombocytopenia caused by immunologic platelet destruction. Diagnosis and treatment of idiopathic thrombocytopenic purpura: Review provided by VeriMed Healthcare Network.
The adalqh treatment of ITP includes: ITP is an autoimmune disease with antibodies detectable against several platelet surface antigens. Idiopathic thrombocytopenic purpura ITP is defined as a hematologic disorder, characterized by isolated thrombocytopenia without a clinically apparent cause. This is because the underlying autoimmune mechanism that is destroying the patient’s platelets will also destroy donor platelets, and so platelet transfusions are not considered a long-term treatment option.
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Immune thrombocytopenic purpura (ITP)
The coating of platelets with IgG renders them susceptible to opsonization and phagocytosis by splenic macrophagesas well by Kupffer cells in the liver. On the 2 nd day after the patient reported, there was increased bleeding, hematoma and gingival enlargement in lower anterior region [ Figure 4 ], and on the 4 th day, hematoma formation was seen in lower anterior region lingually [ Figure 5 ].
Less common are epistaxis, gingival bleeding, and menorrhagia. Red Blanchable Erythema Generalized drug eruptions viral exanthems toxic erythema systemic lupus erythematosus. The idiopayik form often follows an infection and has a spontaneous resolution within two months.
Hypersensitivity and autoimmune diseases No complications were observed and all the lesions were resolved completely. The diagnosis of ITP trombositopenja a diagnosis of exclusion. Archived from the original on Intravenous immunoglobulin IVIg may be infused in some cases in order to decrease the rate at which macrophages consume antibody -tagged platelets. Support Center Support Center.