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Xanthogranulomatous cholecystitis (XGC) is an uncommon The files of the department of histopathology at the. Royal Hallamshire Hospital. Xanthogranulomatous cholecystitis is a rare inflammatory disease of in a review of 40 cases from the Armed Forces Institute of Pathology [3]. General. Uncommon ~ %. Approximately 2% in one series of gallbladders. May be confused (clinically) with gallbladder carcinoma.

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XGC may be histopatholoby high risk of postoperative wound infection and other septic complications because of frequent adhesion and abscess formation. J Am Coll Surg.

Extended surgical resection for xanthogranulomatous cholecystitis mimicking advanced gallbladder carcinoma: Dr Sampurna Roy MD. The lesions appear to result from ruptured Histo;athology sinuses with intramural extravasation of bile and subsequent xanthogranulomatous reaction.

Xanthogranulomatous cholecystitis

The Korean Journal of Internal Medicine ;14 2: XGC is characterized grossly by irregular wall thickening of the gallbladder associated with the formation of yellowish nodules. CASE A year-old uistopathology was admitted to our hospital with a day history of right upper quadrant pain with fever. No metaplasia, nuclear atypia or dysplasia is apparent. It has been suggested that xanthogranulomatous cholecystitis can be divided into two forms: Retrieved from ” https: In conclusion, XGC is difficult to differentiate from other forms of cholecystitis and, sometimes, from gallbladder cancer, clinically and radiologically.

The pathologic findings showed the collection of foamy histiocytes containing abundant lipid in the cytoplasm and admixed lymphoid cells Fig. Magnetic resonance imaging MRI demonstrated diffuse wall thickening of the gallbladder by viewing high signal foci with signal void lesions.


Xanthogranulomatous cholecystitis. Histopathological study and classification.

Infectious etiology of xanthogranulomatous cholecystitis: Gallbladder Cholecystitis Xanthogranulomatous cholecystitis Author: This website is intended for pathologists and laboratory personnel, who understand that medical information is imperfect and must be interpreted using reasonable medical judgment.

The most useful indication of percutaneous needle biopsy would, perhaps, be in advanced gallbladder cancer, as unnecessary laparotomy could be avoided. Postgrad Med J ; Cross sections through the wall revealed multiple yellow-colored, nodule-like lesions ranging from 0. J Clin Pathol 40 4: Eur J Radiol 82 9: A prospective study of 31 cases.

A year-old male was admitted to Chonnam National University Hospital with a day history of right upper quadrant pain with fever. Histopathological study and classification.

In extensive reports, there is a slightly female predominance, which probably reflects the increased incidence of cholecystitis in women 56. Perfidious gallbladders – a diagnostic dilemma with xanthogranulomatous cholecystitis.

Views Read View source View history. The pathologic findings showed the collection of foamy histiocytes containing abundant lipid in the cytoplasm and admixed lymphoid cells x There was no regional lymph node enlargement xanthogranjlomatous focal mass in the liver.

A clinicopathological study of 20 cases and review of the literature.

Xanthogranulomatous cholecystitis is a destructive inflammatory disease of the gallbladder, rarely involving adjacent organs and mimicking an advanced gallbladder carcinoma. Epidemiology of xanthogranulomatous cholecystitis. It means that both XGC and gallbladder cancer are complications of gallstone and inflammation of the gallbladder, or it may suggest that tissue disruption by cancer facilitates extravasation of bile into the gallbladder wall Howard et al 15reported that intraoperative cultures of the bile and gallbladder have been positive usually for Xanthorganulomatous.


Gastroenterol Res Pract Dissection between the gallbladder serosa and hepatic parenchyma was difficult. There was a small-sized abscess in the gallbladder wall near the xanthogranulomatouus duct.

Xanthogranulomatous cholecystitis. Histopathological study and classification.

Pathology of Xanthogranulomatous Cholecystitis. Xanthogranulomatous cholecystitis mimicking stage IV gallbladder cancer. Clinico-pathological study of xanthogranulomatous cholecystitis. DDx gallbladder cholectstitisacute cholecystitis Treatment cholecystectomy surgical removal Xanthogranulomatous cholecystitisabbreviated XGC[1] is an uncommon pathology of the gallbladder.

The sections show a thickened gallbladder wall if cholesterol clefts, multinucleated giant cells, fibrosis and lymphoid aggregates. Rebound tenderness or hepatosplenomegaly was not found. On intraoperative cholangiogram through the cystic duct after cholecystectomy, there was no evidence of remaining stone or bile duct dilatation. Occasionally, XGC may closely mimic a gallbladder cancer or lead to complications such as perforation, abscess and fistula. The pathogenesis of XGC is unclear, although the role of lipid and bile is thought to be important.

Arch Pathoi Lab Med ; Xanthogranulomatous cholecystitis may form a tumour-like mass in inflamed gallbladders. Ultrasonographic examination showed an inhomogenous, hypoechoic wall thickening of the gallbladder with internal small stones, and no dilatation of intrahepatic bile cholecystigis.

Pathology Outlines – Xanthogranulomatous cholecystitis

Microscope – Seeing the Unseen. Xanthogranulomatous cholecystitis XGC is an uncommon, focal or diffuse destructive inflammatory disease of the gallbladder that is assumed to be a variant of conventional chronic cholecystitis.

Cytopathologic diagnosis of xanthogranulomatous cholecystitis and coexistent lesions. Accessed December 31st,