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Comparative hemorheology, in Handbook of Hemorheology and Hemodynamics, eds. O. K. Baskurt, M. R. Hardeman, M. W. Rampling, and. Article · January. Handbook of Hemorheology and Hemodynamics – Ebook download as PDF File .pdf), Text File .txt) or read book online. significantly contribute to hemorheological variations in diseases and in certain extreme physiological properties. KEYWORDS: Hemorheology, hemodynamics, viscosity, erythrocyte deformability, Handbook of Engineering. New York.

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Even moderate hemolysis, which is not an immediate threat to renal function, is an important warning sign of other potential blood cell damage such as platelet handbookk, white blood cell WBC dysfunction, and other serious complications such as scavenging of nitric oxide [1], damage to glycocalyx and endothelial cells, and impairment of the vascular smooth muscle tone [2].

Relations describing fluid flow in cylindrical tubes were formulated by Poiseuille approximately years ago, resulting in the well-known Poiseuille Equation.

The factors that determine the rheological behavior of blood, a two-phase fluid, include the relative volume of each phase as reflected by the hematocrit value, plasma composition and the properties of cellular elements.

In the bridging model, red cell aggregation is proposed to occur when the bridging forces due to the adsorption oc macromolecules onto adjacent cell surfaces exceed disaggregating forces due to electrostatic repulsion, membrane strain and mechanical shearing [15, ]. Abstract In order to quantitatively understand hemodynamiccs conditions of blood flow through various in vitro and in vivo geometries, the flow properties of blood must be experimentally determined.

Ebook: Handbook of Hemorheology and Hemodynamics

What is more, many of those ancient studies were of physical properties of blood that have direct hemorheological relevance. Abstract Inages before there was any concept of blood viscosity, it was appreciated by Anthony van Leeuwenhoek Delft, the Netherlands that red blood cells RBC have to deform in order to negotiate capillary passages [1].

Baskurt oxygen patients perfusion Physiol plasma proteins plasma viscosity plasma volume platelet polycythemia polymer pressure proteins RBC aggregation RBC deformability RBC membrane red blood cells red cell red cell aggregation reduced rheological rheological properties role shear rate shear stress studies surface suspensions syndrome techniques tissue transfusion tube vascular velocity venous venules viscoelasticity viscometer vitro vivo whole blood viscosity.


Selected pages Title Page. Measurements obtained via these methods have been used for monitoring hemodynamic phenomena and diagnosing circulatory disorders, thus providing a deeper understanding of hemodynamic-related diseases in humans [4]. The rate of motion of the cells before capture and the shear forces acting on them during adhesion critically control the efficiency of attachment. The linkage between the in vitro and in vivo research described in the book will be of interest to both basic science and clinical investigators.

Measures of Nemorheology aggregation, such as the erythrocyte sedimentation rate ESRare commonly used as diagnostic tests and as one index to the efficacy of therapy e. Blood viscosity expressed as apparent viscosity i. Pulsatile flow can be hemodynamisc as containing steady plus harmonic components.

Abstract For red blood cells RBC handboo, survive in the harsh hemodynamic environment of the circulation in vivo, they must remain non-adhesive and maintain a set of unique stability. These devices are responsible for saving, extending, and enhancing the lives of patients with otherwise hopeless medical conditions.

If the rate of appearance of publications in the field can be taken as a criterion, hemorheology can be considered as coming of age in the fairly recent past – perhaps forty or so years ago. IV Clinical Aspects of Hemorheology.

This publication primarily focuses on the macro- and micro-rheological behavior of blood and its formed elements, on interactions between the formed elements and blood vessel walls, and on the microvascular aspects of hemodynamics. Since many aspects of hemorheology and hemodynamics are affected by disease or clinical states, these effects are discussed as are hyperviscosity syndromes, therapy for disturbed blood rheology, and methods in hemorheology and hemodynamics.

Abstract In analyzing blood flows, one is generally interested in how the blood responds to forces e. Table 1 presents a classification of hemodynamcis alterations based upon the considerations described above.

These classifications, based on the mechanisms handboo hemorheological alterations, need to be revised in light of developments in the past twenty years. Abstract The development of the fetus, the transition and adaptation at birth, and the subsequent maturation during infancy and childhood require considerable adaptation processes of the macro- and microcirculation.


The rheological equations contain fluid specific characteristics e. However, until fairly recently, progress in this branch of science has been relatively slow, primarily due to the absence of reliable hemorheological laboratory instruments.

Finally, there is a brief review of the variations that occur in other mammals, emphasizing the hwmodynamics and the great differences that exist compared with the human adult. In this chapter no comprehensive treatment of all described methods and techniques has been attempted.

The handbook closes with chapters on clinical states associated with abnormal blood rheology, including a chapter on the yet controversial subject of rheological therapy. Van Leeuwenhoek was far ahead of his contemporary scientists, and although the existence and importance of blood circulation was recognized years later i. The editors of the handbook have each been active in the fields of bio- and hemorheology for many years, and have published extensively.

This publication is not primarily famous for this description of the shear rate dependence of blood viscosity, but rather hemofynamics it pointed out that measurements of blood viscosity in cylindrical tubes could not be used to predict its effects on in vivo blood flow [1]. In selecting topics for this handbook the editors have attempted to provide a general overview of both basic science and clinical hemorheology and hemodynamics.

Handbook of Hemorheology and Hemodynamics – Google Books

The precise mechanisms of blood damage in blood-contacting devices are heterogeneous and are not well understood in spite of numerous investigations of blood trauma conducted over several decades by investigators worldwide. Handbook of Hemorheology and Hemodynamics loading Abstract The circulatory system consists of a pump the heart and an extensive, highly branching system of tubes blood vessels containing a fluid blood with specialized capabilities for the transport of oxygen, nutrients, many other substances and heat.

This early understanding of blood rheology that dominated the first several decades of 20 th century was clearly described in the famous publication of Whittaker and Winton [1].

Macro- and Micro-Rheological Properties of Blood.