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Request PDF on ResearchGate | Dermatitis granulomatosa intersticial con artritis | —Interstitial granulomatous dermatitis with arthritis is a systemic disease. La dermatitis granulomatosa intersticial con artritis es una enfermedad sistémica que afecta a la piel y al sistema musculosquelético. Esta nueva entidad se. Summary. An Orphanet summary for this disease is currently under development. However, other data related to the disease are accessible from the Additional.

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Although TNF-inhibitors dermatitiw been recently described as inducing interstitial granulomatous dermatitis7 etanercept has been used in interstitial granulomatous dermatitis associated with rheumatoid arthritis with complete skin clearance and improvement in granulomatowa.

Julio Bassas aPablo Umbert b. This new entity is characterized by the formation of cords in a linear or arcuate arrangement, although a wide range of clinical presentations has been described. How to cite this article. Services on Demand Journal.

IGD is considered to be a histological inflammatory reaction pattern of the granulomatous type, characterized by collagen necrobiosis, in the intetsticial of an internal disease with the ability to produce immunocomplexes. Ann Dermatol Venereol ; Optimal therapy for this condition is yet to be established, but topical corticosteroids have been a mainstay of treatment.

Pharmacological granulomatossa has also been reported and the most frequently drugs deratitis are the antihypertensives, such as the angiotensin-converting-enzyme inhibitors, calcium channel blockers, beta blockers, diuretics, in addition to hypolipidemic agents, anticonvulsants, antihistamines and TNF-alpha blockers.

If you have any concerns with your skin or its treatment, see a dermatologist for advice. Received Nov 12; Accepted Nov There is less information about associations with palisading neutrophilic granulomatous dermatitis. Considering IGDA as a rare entity, the knowledge of its manifestations and its essential association with rheumatoid arthritis contributes to clinical suspicion, since its wide spectrum presentation makes its diagnosis difficult.


Approved by the Advisory Board and accepted for publication on The characteristic histological features of interstitial defmatitis drug reaction are:. It has been reported in association with several drugs, granulomatos diseases and autoimmune disorders, such as rheumatoid arthritis, systemic lupus erythematosus and vasculitis, but association with autoimmune thyroiditis is rare. Altough the original description reported subcutaneous indurated linear cords “the rope sign” along the lateral aspect of the trunk, the clinical picture is now known to be quite heterogeneous, as it may also manifest as patches, papules, nodules or plaques, and at different body sites.

Interstitial granulomatous dermatitis with cutaneous cords and arthritis: This article has been cited by other articles in PMC. CASE REPORT A year-old Caucasian female presented to the emergency room with 2 erythematous, sharply demarcated, painful, indurated plaques, on her left arm and right thigh, which had appeared in the previous 48 hours. How to cite this article: Print Send to a friend Export reference Mendeley Statistics.

However, several different types of rash have been described with the same histological appearance. Normalization of thyroid function and high-potency topical corticosteroids provided only transitory improvement of the dermatosis. Biopsy examination of a skin specimen showed findings of early interstitial granulomatous dermatitis. Clues to Diagnosis in Dermatopathology. Clin Rheumatol Show more Show less.

Open in a separate window. Abstract Besides being an uncommon clinicopathological entity, interstitial granulomatous dermatitis, also described as interstitial granulomatous dermatitis with arthritis IGDAhas shown a wide spectrum of clinical manifestations, such as linear and erythematous lesions, papules, plaques and nodules.

Granulomatous dermatitis

For all other comments, please send your remarks via contact us. DermNet NZ does not provide an online consultation service. If you are a member of the AEDV: Granuloma annulare is less often associated with auto-immune diseases. Continuing navigation will be considered as acceptance of this use.


Granuloma annulare and interstitial granulomatous dermatitis may appear similar clinically and histologically. A review of the cutaneous manifestations. Are you a health professional able to prescribe or dispense drugs?

Dermatitis granulomatosa intersticial con artritis | Actas Dermo-Sifiliográficas (English Edition)

The main associated disease is RA, which may be diagnosed before, concomitantly or after the onset of lesions. Check this box if you wish to receive a copy of your message. The typical microscopic presentation should be that of a granulomatous dermatitis, with palisading or interstitial histiocytes, variable numbers of neutrophils and eosinophils, and scattered areas of degenerating collagen bundles.

The clinical case report of a year-old diabetic teenager with undifferentiated juvenile arthritis and 2- years history of skin-colored maculae and plaques is presented. Interstitial granulomatous dermatitis is a rare skin disorder in which there is a particular pattern of granulomatous inflammation.

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Granulomatous dermatitis | DermNet NZ

The characteristic histological features of granuloma annulare are:. The histopathological examination defines the diagnosis characterized as dense and diffuse interstitial infiltrate in the reticular dermis, composed of histiocytes in a palisade arrangement, sometimes with necrobiosis of interstiical and involved by some neutrophils and eosinophils. Skin biopsy was compatible with interstitial granulomatous dermatitis.

Its clinical manifestations are variable.

Gdanulomatosa of the process in the reticular dermis is a characteristic feature, although abnormalities can involve the full thickness of the dermis or the superficial hypodermis.