Introduction: Juvenile nasopharyngeal angiofibroma is a rare, highly .. Luiz A CR, Romualdo S LT, Fava A S. Angiofibroma nasofaríngeo: revisão de literatura. Juvenile nasopharyngeal angiofibroma (JNA) is a rare benign tumor arising predominantly in the nasopharynx of adolescent males. It is an aggressive. Juvenile nasopharyngeal angiofibromas (JNA) are a rare benign but locally aggressive vascular tumor. Epidemiology Juvenile nasopharyngeal angiofibromas.
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The most solid basic knowledge regarding the JNA is pursuant to its histology.
Nasopharyngeal angiofibroma: Our experience and literature review
The nature nasofaringo juvenile nasopharyngeal angiofibroma. The histologic origin of JNA involves vascular endothelial cells or fibroblasts. Universidade Federal de Sergipe.
Like any other solid tumor, the JNA depends on the growth of vessels that offer intake to its proliferation and growth, which justifies the search for proangiogenic growth factors in its pathogenesis.
Endoscopic surgery alone or with other conventional techniques was safe for the treatment of angiofibromas of different angiofibro,a. The 3 patients who underwent combined surgeries experienced intraoperative bleeding, requiring nasal packing and replacement of blood products during surgery. Juvenile nasopharyngeal angiofibroma JNA is a rare benign tumor arising predominantly in the nasopharynx of adolescent males.
The angiofibroka concern regarding the choice of pathway is the rate of tumor recurrence, which has generated much discussion.
Pathology Outlines – Nasopharyngeal angiofibroma
The endoscopic resection is best indicated for small tumors confined to the nasopharynx, nasal cavity, ethmoid and sphenoid, and in some cases, tumors with nasofraingeo into the pterygopalatine fossa 4.
Role of TGF-beta in cancer nasotaringeo the potential for therapy and prevention. The GSTM1 glutationa-S-transferase M1 gene, constitutively expressed in the human cells and that has antioxidant cytoprotector properties, has its loss of expression associated to smoke and to the development of malignity in the upper respiratory passages tract. Xngiofibroma carcinoma Adenocarcinoma Mucinous cystadenocarcinoma Large-cell lung carcinoma Rhabdoid carcinoma Sarcomatoid carcinoma Carcinoid Salivary gland—like carcinoma Adenosquamous carcinoma Angiovibroma adenocarcinoma Giant-cell carcinoma.
In addition, preoperative embolization may complicate the identification of the full extent of surgical margins by reducing the tumor size and increasing the risk of relapse This website is intended for pathologists and laboratory personnel, who understand that medical information is imperfect and must be interpreted using reasonable medical judgment.
Medical treatment and radiation therapy are only of historical interest. Vessel density, proliferation, and immunol immunolocalization of vascular endothelial growth factor in juvenile nasopharyngeal angiofbromas. Efforts to determine the pathogenesis of the tumor have been done by studying the expression of various growth factors and oncogenes such as C-KIT and C-MYC. Treatment trends in patients during 40 years. Besides, it was observed that with the fibrous component development the bleeding trend decreases 9.
In the JNA, anti-androgenic agents like flutamide may reduce the growth rate of the JNA in vitro 40and besides the androgen receptor, other nasofarigneo receptors have already been detected 39, This syndrome is a dominant autossomal condition characterized by several adenomas nasofarigeo the gastrointestinal tract, trend for the development of adenocarcinomas and extraintestinal manifestations.
DSA digital subtraction angiography of carotid artery to see the extension of tumors and feeding vessels. The JNA is a highly vascularized tumor and its probable original site is in the upper margin of the sphenopalatine foramen 1,3.
The genetic alterations observed more often involve sex chromosomes. Thus, early diagnosis, accurate staging, and adequate treatment are essential in the nasofaringep of this lesion.
The classification and clinical staging is relatively easy and helps to plan treatment and determine prognosis. All patients were treated surgically, including 17 who underwent endoscopic surgery. Recent advances in the treatment of juvenile angiofibroma.
We also found that patients who underwent clamping of the external carotid artery and embolization showed less intraoperative bleeding than patients who underwent embolization alone.
Patients may present with life-threatening epistaxis. Variables analyzed included patient age, sex, symptoms, tumor stage, treatment, duration of surgery, volume of intraoperative bleeding, need for nasal packing after surgery, length of hospitalization, immediate and late complications, recurrence, and preoperative embolization and clamping of the external carotid during surgery.
Such predictors will be able to help in the patients follow-up angjofibroma surgical removal. Juvenile nasopharyngeal angiofibroma originates in the sphenopalatine forame, causing epistaxes and nasal obstruction.
MRI is used posttreatment to detect residual or recurrent tumor mass and to monitor the effects of radiotherapy. Accordingly, the treatment options, operative approach and prognosis can be determined. Consistent expression of estrogen receptor beta. Classically, the JNA may have an aspect similar to the erectile tissue; to a cavernous hemangioma with fibrous stroma or to a fibromatosis.
Preoperative embolisation of tumour may be of some use in reducing intraoperative bleeding. How to cite this article.
Loss of expression of GSTM 1 null genotype is seen in this tumor. Patient number three on the eve of surgery angiofibrima for respiratory failure and high occupancy by the nose and oropharynx by nasoangiofibroma. The VEGF is expressed specially in the stromal cells and JNA vessels and is associated to the proliferation and high vascular density of the tumor regions Classification of Fisch Type I: Proliferation, angiogenesis and hormonal markers in juvenile nasopharyngeal angiofibroma.
Treatment trends in patients during 40 years.
Kaklamani VG, Pasche B. External carotid clamping has been shown to assist in hemostasis of the tumor. The second patient, also with a Fisch I tumor, underwent clamping of the external carotid arteries without embolization.
Specifically, genes of Rab via and proteins of connection to the retinoblastoma, among others, were found in several amplified regions and both of them have their overexpression associated to other tumors.
However, recurrence reflects an initial incomplete resection. At the time of nasofwringeo, the mass classically involves the pterygopalatine fossa. Several classification methods have been utilized to stage tumors and assist in choosing the appropriate treatment.